You are looking at developing a drug to help with transplantations, by trying to prevent naïve Helper T Cells from activation (remember that naïve T Cells are mature, they just have not recognized their antigen/MHC complex yet). Because the transplanted tissue has probably never been seen by the immune system, you are not to worry about memory T Cells. Your goal is to prevent the antibody response by preventing the Helper T Cells from activating the B Cell response to the tissue.
WHAT YOU SHOULD KNOW BEFORE YOU START:
EXTRA CREDIT (up to 5pts)
Explain a mechanism you could target to prevent just the B Cells from being able to be activated, without targeting any part of the T Cell.
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