What is retinoblastoma, and what is the pattern of inheritance for this type of cancer?
Case study A 2 two year old male presents with a retinal tumor and ultimately Retinoblastoma. 1. What is retinoblastoma, and what is the pattern of inheritance for this type of cancer? 2. What type of gene is the retinoblastoma gene, and how does mutation in this gene give rise to cancer? Be sure to indicate the consequences of mutating one or both of the alleles for this gene. 3. What is the difference between a germline and a somatic mutation? 4. What is the normal function of the pRB protein with regard to cell cycle regulation? APA 7th edition, please evidence-based literature and primary sources that are up to date and are most desirable. Works such as WebMD and the patient “self-help” resources are not appropriate for graduate discussions.
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