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Purdue Global University Mechanisms of Endocrine Control Discussion

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In your discussion, be sure to discuss developing collaborative relationships with clients when teaching concepts concerning pathological states to individuals and families.

Case Study Assignment Requirements

  1. Make sure all of the topics in the case study have been addressed.
  2. Cite at least three references in your case study paper; this may include peer-reviewed journal articles, textbooks, or evidence-based practice websites to support the content.
  3. All reference sources must be within 5 years.
  4. Do not use sources such as Wikipedia or UpToDate as a reference.
  5. Assignments must have at least four full pages of analytic content, double-spaced (the cover and reference pages do not count in the page count, but must be included with the assignment), and follow APA 7th edition format.
  1. Case Study 4: Mechanisms of Endocrine ControlLeda is a 38-year-old woman who began to experience weight gain, mood swings, and weakness. When her periods became irregular, she went to her physician. Leda’s physician heard the symptoms Leda was concerned about and then ordered a 24-hour free cortisol urine test and an overnight dexamethasone suppression test and measured her serum ACTH levels. The results indicated that Leda had Cushing disease, a condition caused by the hypersecretion of ACTH by the anterior pituitary and resulting in elevated cortisol levels. To confirm the diagnosis, Leda’s physician ordered a cranial MRI to identify the presence of a pituitary tumor.
    1. The dexamethasone test involves the administration of a synthetic glucocorticoid (e., cortisol). Knowing what you do about negative feedback mechanisms, how might this test be used to assess pituitary function?
    2. Describe how the steroid hormones, like cortisol, are metabolized in the body. What are the advantages of using a 24-hour urine test to measure this hormone?
    3. Protein-based and steroid-based hormones trigger cellular responses in different ways. What are the differences between the mechanism of action of ACTH and cortisol on target cells?

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