1. Write a comprehensive but yet efficient and realistic approach to meet the goals and objectives of projects listed below. In your proposal include following sections:
-INTRODUCTION (1 page)
-METHODS (1 page)
-DISSCUSION (2 pages)
-CONCLUSION (1/2 page)
2. Style of the paper:
Text style: Arial or Times New Roman
Font: 11
Line spacing: single
3. What you should include in the Essay:
You should discuss in your proposal (essay) about strengths and weaknesses of each technique/approach you propose to use and explain why you selected them for your project (at least four different techniques must be included in your proposal). Explain in your proposal if and how exactly you can use these techniques/methods to address specific goals and objectives listed in your project. Along with this, provide rational (by citing literature, lecture notes or textbooks) why did you include or exclude particular methods or techniques. Finally, discuss in your proposal about possible problems and obstacles that you may encounter in the course of proposed study, and propose alternative strategies. Please be specific and provide examples for your statements in your proposal (again by citing literature, lecture notes or textbooks)!
Helpful tips: The main goal is to write focused, analytical proposal. Avoid writing long, purely descriptive and general sections!
4. What Each part should include or consist of:
Introduction: explain aims and objectives of the project and list technique you propose to use; explain/discuss biological relevance of the project.
Methods: give background information about each technique that “you propose to use”: explain how they work, what types of parameters and events you can measure with these techniques, and list advantages and disadvantages of each technique taking into account goals and specifics of your project!
Discussion: explain how each technique pertains to aims and objectives of your project, what parameters would you measure, and describe experimental steps that would allow you to test aims of the project; what are the obstacles (i.e. technical limitations of technique) and what are the alternative strategies (i.e. you can propose to use combination of techniques). In this section you should also be specific.
Conclusion: a short summary of project and experimental approaches (single paragraph).
5. The topic in which the paper should talk about is the SNARE protein complex and below is more details about it:
The main objective of this project is to characterize organization and structure of SNARE macromolecular complex. SNARE complex is a ~70 kDa membrane-associated heteroptotein complexes formed by self assembly of three SNARE proteins (Syntaxin-1/SNAP-25/VAMP-2). Studying dynamics of complex assembly is also one of the important milestones of this project.
6. I attached a powerpoint presentation that was done following exactly the same order in which this paper should be written about the same topic as well which is SNARE complex. it should help you a lot in writing the paper, you can use it to base the paper off of it and just change a few of the techniques.
Lastly, I am willing to extend it to 30 hours if you ever need it,
Thank you!
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