In Module 3, Lecture 1, we learned about the four core principles of human subjects research (autonomy, beneficence, nonmaleficence, and justice) .For this assignment, consider what you read in Perusall activity by Johnston and Baylis (2004). Johnston and Baylis describe an older case of genome editing therapy for a disease called X-linked SCID (Severe Combined Immune Deficiency). Following a novel gene therapy for their X-linked SCID, two children in the clinical trial developed leukaemia. This article provides a case study of risks associated with genome editing for biomedical therapies.
Johnston and Baylis article: “Gene Therapy:Two Steps Forward, one Step back”
In at least 250 words (total):
(1) Identify one of the four core principles of human subjects research at stake with this case. Explain why you think that the core principle you have chosen applies to this case.
(2) Using the case describe in the Johnston and Baylis article, do the following:
(a) Identify an ethical problem in the case. Explain why you believe that this is an ethical problem.
(b) Identify ONE interested individual or institution (stakeholder) in this case. Explain why you believe that this individual or institution is a stakeholder in this case.
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