Unit 10 Verify Activity 1. You take part in the annual Coney Island Polar Bear Plunge and jump into frigid ocean water. The blood vessels in your skin vasoconstrict and systemic vascular resistance increases. As a result, your MAP increases from 93 mmHg to 120 mmHg.
Describe in a few sentences the two types of autoregulatory mechanisms that will maintain your GFR at normal levels (180 L/day)
Unit 10 Verify Activity 2.
a) The renal clearance of glucose is normally zero. Write a sentence or two and explain why glucose is present in the urine of an unmanaged type 1 diabetic (type 1 diabetics can’t produce endogenous insulin).
c) Propose a mechanism for a drug to treat type 2 diabetes (elevated blood glucose levels).
Zombie Apocalypse Bonus Activity
Manhattan is ground zero for an invasion of the living dead. The origin of the first case remains unknown, but the number of flesh-eating zombies is growing exponentially*. Food abounds in the densely-populated Gotham City, and it is now common to see people being eaten alive on the street.
The only known method for killing the zombies permanently is a gunshot wound to the head, or some other method that destroys their brains. This approach is proving ineffectual. Their numbers are growing unchecked and panic has gripped the City. Even trained military sharpshooters are unable to eliminate the ghouls fast enough to outpace their emergence.
You make a key observation when you see a group of zombies crowded around a leaky fire hydrant, eagerly lapping up water. You surmise that their high-protein diet generates a lot of nitrogenous waste products. In addition to a nervous system for controlling locomotion, you realize that the living dead must have a way to eliminate nitrogenous wastes.
Anecdotal reports have surfaced that zombies have kidney-like structures, but you know that shooting their kidneys with bullets will be even more ineffectual than shooting their brains; another approach is necessary. Your objective is to develop a method for permanently killing zombies that targets their ability to eliminate nitrogenous wastes. You must also address the potential impact your method will have on the normal human population.
This activity is worth 25 bonus points and is due April 30 at 11:59pm.
- Do NOT propose shooting the zombies with any sort of conventional projectile (such as a bullet).
- Do NOT propose restricting the zombie’s access to water.
- You MUST address how your approach will impact the human population and how you will limit collateral damage.
*The condition of being a ’zombie’ (also known as ‘the living dead’ or ‘walking dead’ or ‘undead’) is recognized by the medical community as Ataxic Neurodegenerative Satiety Deficiency Syndrome (ANSDS). The syndrome is thought to be caused by an airborne prion; the prion can also be passed to victims through a bite that breaks the skin. Symptoms include progressive loss of brain tissue, uncoordinated (ataxic) gait, and an insatiable hunger for human flesh.
This activity was inspired by:
https://www.cdc.gov/cpr/zombie/index.htm
The Zombie Autopsies: Secret Notebooks from the Apocalypse, by Steven C. Schlozman, MD
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